Recombinant Human IL-23 Protein(Fc Tag) (PDMH100317)
For research use only.
| Synonyms | UNQ, PRO, IL-23, IL-23A, IL23A, SGRF, UNQ2498, PRO5798 |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Arg20-Pro189 |
| Accession | Q9NPF7 |
| Calculated Molecular Weight | 43.6 kDa |
| Observed Molecular Weight | 45 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | IL-23 , which is mainly secreted by antigen-presenting cells , is a member of the IL-12 family , which includes IL-12 , IL-27 , and IL-35. IL-23 is a heterodimeric cytokine , comprised of a unique p19 subunit and p4 subunit , the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1 , the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation , expansion , and survival by binding to its receptor , thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases , such as autoimmune arthritis , primary biliary cirrhosis , and inflammatory bowel disease. |
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