Recombinant Human GITR/TNFRSF18 Protein(Fc Tag) (PDMH100336)
For research use only.
| Synonyms | UNQ, PRO, Tumor necrosis factor receptor superfamily member, Tnfrsf, CD357, Glucocorticoid-induced TNFR-related protein, Tumor necrosis factor receptor superfamily member 18, AITR, GITR, TNFRSF18, UNQ319, PRO364, GITR, AITR |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Gln26-Glu161 |
| Accession | Q9Y5U5 |
| Calculated Molecular Weight | 39.9 kDa |
| Observed Molecular Weight | 45 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway. |
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