Recombinant Human GDF2 Protein(His Tag) (PDEH101121)
For research use only.
| Synonyms | Bone morphogenetic protein 9, BMP-9, Growth/differentiation factor 2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ser320-Arg429 |
| Accession | Q9UK05 |
| Calculated Molecular Weight | 11.9 kDa |
| Observed Molecular Weight | 12 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | BMPs belong to the TGF-β superfamily, which currently has over 20 members. BMPs play a vital role in several processes, such as embryogenesis and tissue homeostasis; thus, they are also known as body morphogenetic proteins.9 BMP2, BMP6 and BMP7 are deeply involved in inflammatory disorders, including fibrosis, inflammatory bowel disease, ankylosing spondylitis, and rheumatoid arthritis. BMP9 is considered a unique member of the BMP family as it has the strongest osteogenic effect on mesenchymal stem cells (MSCs), is resistant to the BMP signaling inhibitors, noggin and BMP3,nd significantly affects vascular homeostasis, angiogenesis, metabolism, neurogenesis, and pro- or anti-tumorigenesis. |
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