Recombinant Human GCDH Protein (His Tag) (PKSH032495)
For research use only.
| Synonyms | GCD, GCDH, Glutaryl-CoA Dehydrogenase Mitochondrial |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Arg45-Lys438 |
| Accession | Q92947 |
| Calculated Molecular Weight | 45.0 kDa |
| Observed Molecular Weight | 41 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
| Background | Glutaryl-CoA Dehydrogenase Mitochondrial (GCDH) is an enzyme that acts upon glutaryl-coenzyme A, creating crotonyl-coenzyme A. It plays a role in the metabolism of lysine, hydroxylysine and tryptophan. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive Glutaryl-CoA and electron-transfer flavoprotein to (E)-but-2-enoyl-CoA, CO2 and reduced electron-transfer flavoprotein. A defect in this enzyme is associated with neurological condition glutaric acidemia type 1 and cause a progressive form of early-onset generalized dystonia. |
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