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Recombinant Human ERN1/IRE1 Protein (aa 465-977, His & GST Tag) (PKSH030346)

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50μg $ 580.00
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For research use only.

Synonyms IRE1, IRE1P, IRE1a, hIRE1p
Species Human
Expression Host Baculovirus-Insect Cells
Sequence Pro 465-Leu 977
Accession O75460-1
Calculated Molecular Weight 86.0 kDa
Observed Molecular Weight 90 kDa
Tag N-His-GST
Bio-activity The specific activity was determined to be 5 nmol/min/mg using MBP as substrate
Purity > 80 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as sterile solution of 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.4
Reconstitution Not Applicable
Background The encoded protein contains two functional catalytic domains; a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins; regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
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