Recombinant Human EpCAM/TROP-1 Protein(His Tag) (PDMH100313)
For research use only.
| Synonyms | M4S, MIC, M1S, DIAR, TROP, HNPCC, GA733, TACSTD, EGP, EPCAM, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, Ep-CAM, epithelial cell adhesion molecule, GA733-2, M1S2, MK-1, KSA, EGP40, TROP1, 17 1A, 323/A3, 35-KD glycoprotein, Adenocarcinoma associated antigen, Adenocarcinoma-associated antigen, Antigen identified by monoclonal AUA1, AUA1, CD326, CD326 antigen, Cell surface glycoprotein Trop 1, Cell surface glycoprotein Trop 2, Cell surface glycoprotein Trop-1, chromosome 4, CO 17A, CO17 1A, CO17A, EGP 2, EGP2, Ep CAM, EpCAM1, Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD), Epithelial cell surface antigen, Epithelial cellular adhesion molecule, Epithelial glycoprotein, Epithelial glycoprotein 1, Epithelial glycoprotein 314, EpithelialGlycoprotein, GA733 1, GA733 2, gastrointestinal tumor-associated antigen 2, gp4, hEGP 2, hEGP314, Human epithelial glycoprotein 2, KS 1/4 antigen, KS 1/4 antigen.KSA, Ly74, Lymphocyte antigen 74, M1S 1, Major gastrointestinal tumor associated protein GA733 2, Major gastrointestinal tumor-associated protein GA733-2, mEGP314, Membrane component, Membrane component chromosome 4 surface marker (35kD glycoprotein), MK 1, Protein 289A, surface marker, surface marker 1, TACD1, Tumor associated calcium signal transducer 1, Tumor associated calcium signal transducer 2 precursor, Tumor-associated calcium signal transducer 1 |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Gln24-Lys265 |
| Accession | P16422 |
| Calculated Molecular Weight | 26.5 kDa |
| Observed Molecular Weight | 35 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Epithelial Cell Adhesion Molecule (EpCAM) , also known as GA733-2 antigen , is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region , a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage , high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However , recent insights have revealed that EpCAM participates in not only cell adhesion , but also in proliferation , migration and differentiation of cells. In addition , recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain , which can signal into the cell nucleus by engagement of elements of the wnt pathway. |
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