Recombinant Human dUTPase Protein (PKSH032364)

For research use only.
Synonyms | DUT, Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondrial, dUTP Pyrophosphatase, dUTPase |
Species | Human |
Expression Host | E.coli |
Sequence | Met 1-Asn164 |
Accession | P33316-2 |
Calculated Molecular Weight | 17.7 kDa |
Observed Molecular Weight | 17 kDa |
Tag | None |
Bio-activity | Not validated for activity |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
Reconstitution | Not Applicable |
Background | Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondrial (dUTPase) belongs to the dUTPase family. dUTPase exits as a homotrimer and is involved in nucleotide metabolism. dUTPase produces dUMP; the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. The dUTPase increase in PCR product yield; length and fidelity enables further down-stream applications. These effects make dUTPase useful in PCR fidelity and yield-sensitive applications. dUTPase is specific for dUTP and is critical for the fidelity of DNA replication and repair. |
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