Recombinant Human CXCL7/NAP-2 Protein(Sumo Tag) (PDEH100572)
For research use only.
| Synonyms | B-TG, CTAP, CXCL, SCYB, C-X-C Motif Chemokine, MDGFSmall-Inducible Cytokine B, LA-PF, NAP, PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, C-X-C Motif Chemokine 7, Leukocyte-Derived Growth Factor, Macrophage-Derived Growth Factor, MDGFSmall-Inducible Cytokine B7, NAP2, Platelet Basic Protein, βTG, B TG1, Beta TG, Beta thromboglobulin, beta-1, Chemokine (C X C motif) ligand 7, Connective tissue activating peptide III, CTAP 3, CTAP III, CTAP-III(1-81), CXC chemokine ligand 7, CXCL 7, LA PF 4, Leukocyte derived growth factor, Low-affinity platelet factor IV, NAP 2, NAP-2(1-63), NAP-2(1-66), NAP-2(73), NAP-2(74), Neutrophil activating peptide 2, Neutrophil-activating peptide 2(1-63), Pro platelet basic protein, Pro platelet basic protein (chemokine (C-X-C motif) ligand 7), Pro-Platelet basic protein, Small inducible cytokine subfamily B member 7, Small-inducible cytokine B7, Thrombocidin 1, Thrombocidin 2, Thromboglobulin, βTG, PBP, CXCL7, NAP2, β-thromboglobulin |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala59-Asp128 |
| Accession | P02775 |
| Calculated Molecular Weight | 20.59 kDa |
| Observed Molecular Weight | 25 kDa |
| Tag | N-Sumo |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis , mitosis , glycolysis , intracellular cAMP accumulation , prostaglandin E2 secretion , and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2 , and Nap-2 , Nap-2 (73) , Nap-2 (74) , Nap-2 (1-66) , and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils. |
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