Recombinant Human CXCL2 Protein(Trx Tag) (PDEH100573)
For research use only.
| Synonyms | GRO, MIP, CXCL, SCYB, C-X-C Motif Chemokine, CXCL2, CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, MIP2, MIP2A, SCYB2, CINC2a, C-X-C Motif Chemokine 2, GRO beta, Gro-Beta, Growth-Regulated Protein Beta, Macrophage Inflammatory Protein 2-Alpha, MIP2-Alpha |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala35-Asn107 |
| Accession | P19875 |
| Calculated Molecular Weight | 27.9 kDa |
| Observed Molecular Weight | 30 kDa |
| Tag | N-Trx |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Chemokine (C-X-C motif) ligand 2 (CXCL2) , also called macrophage inflammatory protein 2 (MIP-2) , Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2) , is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone , where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2 , peripheral tolerance is prevented , and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone , where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2 , peripheral tolerance is prevented , and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity , graft acceptance , and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz , crocidolite asbestos , as well as high doses of other relative innocuous dusts such as titanium dioxide. |
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