Recombinant Human CD40 Protein(His Tag) (PDMH100223)
For research use only.
| Synonyms | AI326936, B cell associated molecule CD40, B cell surface antigen CD40, B cell-associated molecule, B-cell surface antigen CD40, Bp50, CD 40, CD40, CD40 antigen (TNF receptor superfamily member 5), CD40 antigen, CD40 molecule, CD40 molecule, TNF receptor superfamily member 5, CD40 protein, CD40 type II isoform, CD40L receptor, CDw40, GP39, HIGM1, IGM, IMD3, MGC9013, Nerve growth factor receptor related B lymphocyte activation molecule, OTTHUMP00000031699, OTTHUMP00000031700, p50, T-BAM, TBAM, TNF receptor superfamily member 5, TNFRSF5, TNR5, TRAP, Tumor necrosis factor receptor superfamily, member 5, Tumor necrosis factor receptor superfamily member 5, Tumor necrosis factor receptor superfamily member 5 precursor, Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Glu21-Arg193 |
| Accession | P25942 |
| Calculated Molecular Weight | 18.9 kDa |
| Observed Molecular Weight | 25-35 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. |
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