Recombinant Human CD10/Neprilysin Protein (His Tag) (PKSH033583)
For research use only.
| Synonyms | SCA, Neutral endopeptidase 24., CALLA, CD10, CMT2T, NEP, SCA43, SFE, MME, Atriopeptidase, Common acute lymphocytic leukemia antigen, Enkephalinase, Neprilysin, Neutral endopeptidase, Neutral endopeptidase 24.11, Skin fibroblast elastase, EPN, NEP, gp100, CD10 antigen, CD10), DKFZp686O16152, EC 3.4.24.11, enkephalinase), Membrane metallo endopeptidase, Membrane metallo endopeptidase (neutral endopeptidase, Membrane metallo endopeptidase variant 1, Membrane metallo endopeptidase variant 2, Membrane metalloendopeptidase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10, Membrane metalloendopeptidase variant 1, Membrane metalloendopeptidase variant 2, membrane-associated, MGC126681, MGC126707, neprilysin-390, neprilysin-411 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Tyr52-Trp750 |
| Accession | P08473 |
| Calculated Molecular Weight | 80.9 kDa |
| Observed Molecular Weight | 94-100 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
| Background | Neprilysin/CD10(NEP) is a zinc metallopeptidase expressed at the cell surface of a variety of cells. The functions is both as an endopeptidase with a thermolysin-like specificity and as a dipeptidyl-carboxypeptidase. NEP has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. NEP has also been identified as the common acute lymphocytic leukemia antigen (CALLA), and is expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable interest in NEP as a target for analgesics and antihypertensive drugs. NEP is also a major degrading enzyme of amyloid β peptide (Aβ) in the brain, indicating that down-regulation of NEP activity, which could be caused by aging, can contribute to the development of Alzheimer’s disease by promoting Aβ accumulation. |
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