Recombinant Human BRCA2 Protein (His Tag) (PDEH100705)
For research use only.
| Synonyms | BRCA 2, BRCA1/BRCA2 containing complex subunit 2, BRCA2, BRCC 2, BRCC2, Brca2, Breast Cancer 2 t, Breast and ovarian cancer susceptibility gene early onset, Breast cancer 2 early onset, DNA repair associated, breast and ovarian cancer susceptibility protein 2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Thr2350-Val2545 |
| Accession | P51587-1 |
| Calculated Molecular Weight | 22.1 kDa |
| Observed Molecular Weight | 25.4 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 85% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. |
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