Recombinant Human BMP6 Protein(Fc Tag) (PDMH100266)
For research use only.
| Synonyms | BMP-6, Bmp6, BMP6, Bone morphogenetic protein 6, Bone Morphogenic Protein 6, Decapentaplegic vegetal related, DVR6, HGNC:12686, TGFB related vegetal related growth factor, Transforming growth factor beta, Vegetal related (TGFB related) cytokine, Vegetal related growth factor (TGFB related), Vg related sequence, VG-1-R, VG-1-related protein, Vg1 related sequence, VGR, VGR-1, VGR1 |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Ser375-His513 |
| Accession | P22004 |
| Calculated Molecular Weight | 40.2 kDa |
| Observed Molecular Weight | 42 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. |
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