Recombinant Human Autotaxin/ENPP2 Protein (aa 36-863, His Tag) (PKSH033693)
For research use only.
| Synonyms | ATX, ATX-X, ATXFLJ26803, Autotaxin, E-NPP 2, EC 3.1.4.39, ENPP2, LysoPLD, NPP2, PD-IALPHA, PDNP2, PDNP2NPP2, autotaxin-t, ectonucleotide pyrophosphatase/phosphodiesterase 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala36-Ile863 |
| Accession | AAH34961.1 |
| Calculated Molecular Weight | 96 kDa |
| Observed Molecular Weight | 100-120 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of 20mMPB,150mMNaCl,pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain.Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung. |
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