Recombinant Human APOA4 Protein(Sumo Tag) (PDEH100609)
For research use only.
| Synonyms | Apolipoprotein A, APOA4, Apo AIV, APOA 4, ApoA IV, ApoAIV, ApoA-IV, Apo-AIV, Apolipoprotein A IV, Apolipoprotein A4, Apolipoprotein A-IV, MGC142154, MGC142156, APOA4, Apolipoprotein A-IV, ApoA-IV, ApoAIV, apoA4, |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ser23-Ser396 |
| Accession | P06727 |
| Calculated Molecular Weight | 54 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | N-Sumo |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD). The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11. There was a decreased trend for levels of APOA1, APOC3, and APOA4 in AD patients. CONCLUSION: Low levels of APOA1, APOC3, and APOA4 are associated with risk of AD. APOA1, APOC3, and APOA4 should be developed as combined drμgs for the therapy of AD. SNP(single nucleotide polymorphisms)in APOA1and APOA4 genes influences atherogenic characteristics of LDL particles in response to diet. |
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