Recombinant Human ANGPTL4 Protein(hIgG1 Fc Tag) (PDMH100444)
For research use only.
| Synonyms | UNQ, ARP, PRO, PSEC, angiopoietin like, Secreted protein Bk, Angiopoietin like protein, Angiopoietin-like protein, Angiopoietin related protein, Angiopoietin-related protein, ANGPTL, 425O18, ANGPTL4, ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158, 425O18-1, Angiopoietin-like protein 4, Angiopoietin-related protein 4, Farp, Fasting-induced adipose factor, Hepatic fibrinogen/angiopoietin-related protein, Ng27, Secreted protein Bk89, PSEC0166, angiopoietin like 4, Angiopoietin like protein 4, Angiopoietin related protein 4, PRO197 |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Arg164-Ser406 |
| Accession | Q9BY76 |
| Calculated Molecular Weight | 51.6 kDa |
| Observed Molecular Weight | 58 kDa |
| Tag | C-hIgG1 Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It contains 1 fibrinogen C-terminal domain and is expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may also exert a protective function on endothelial cells through an endocrine action. ANGPTL4 is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. |
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