Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag) (PKSH033782)
For research use only.
| Synonyms | ACVRL1, ACVRLK1, ALK-1, ALK1, Activin Receptor-Like Kinase 1, HHT, HHT2, ORW2, SKR3, Serine/Threonine-Protein Kinase Receptor R3, TGF-B Superfamily Receptor Type I, TSR-I |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp22-Gln118 |
| Accession | P37023 |
| Calculated Molecular Weight | 37.6 kDa |
| Observed Molecular Weight | 50-65 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-βsuperfamily of ligands. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. The mutations of ALK-1 are associated with Rendu-Osler-Weber syndrome 2, this suggests ACVRL1 is associated with blood vessel development and repair. |
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