Recombinant Human AKR1C2 Protein (PKSH032054)
For research use only.
| Synonyms | 2-Dihydrobenzene-1, 2-Diol Dehydrogenase, 3-Alpha-HSD3, Aldo-Keto Reductase Family 1 Member C2, Chlordecone Reductase Homolog HAKRD, DD-2, DD/BABP, DD2, Dihydrodiol Dehydrogenase 2, Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein, Trans-1, Type III 3-Alpha-Hydro |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Tyr323 |
| Accession | P52895 |
| Calculated Molecular Weight | 36.7 kDa |
| Observed Molecular Weight | 35 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, pH 8.0. |
| Reconstitution | Not Applicable |
| Background | Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol). |
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