Recombinant HER2/ErbB2/CD340 Monoclonal Antibody (AN300004P)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human breast carcinoma Verified Samples in IF: SKBR3 Verified Samples in FCM: MCF-7 |
| Dilution | IHC-P 1:100-1:500, ICC/IF 1:20-1:100, FCM 1:25-1:100, |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P, FCM, ICC/IF |
| Clonality | Rabbit Monoclonal |
| Immunogen | Recombinant Human HER2/ErbB2/CD340 Protein |
| Abbre | ERBB2 |
| Synonyms | TKR, ERBB, erb-b2 receptor tyrosine kinase, Receptor tyrosine-protein kinase erbB, Tyrosine kinase-type cell surface receptor HER, HER2/ErbB, HER, MLN, ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2, HER2/ErbB2, MLN19, Metastatic lymph node gene 19 protein, p185, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2, Neu, erb-B2, CD340, erb-b2 receptor tyrosine kinase 2, HER2, HER-2, HER-2/neu, MLN 19, MLN19, NGL, TKR1, C erb B2/neu protein, CD340 antigen, Cerb B2/neu protein, CerbB2, ENV, ENVW, Erb b2 receptor tyrosine kinase 2, ERVWE1, HER 2, HER 2/NEU, Herstatin, HERV7Q, HERV-7q, HERVW, HERVWENV, HERV-W-ENV, Human epidermal growth factor receptor 2, NEU proto oncogene, neuro/glioblastoma derived oncogene homolog, neuro/glioblastoma derived oncogene homolog (avian), Neuroblastoma/glioblastoma derived oncogene homolog, p185erbB2, Proto-oncogene c-ErbB-2, Tyrosine kinase type cell surface receptor HER2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog), V erb b2 avian erythroblastic leukemia viral oncoprotein 2, V erb b2 erythroblastic leukemia viral oncogene homolog 2, Verb b2 erythroblastic leukemia viral oncogene homolog 2 |
| Swissprot | |
| Cellular Localization | Cell membrane |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Tags & Cell Markers, Signal Transduction, Cancer |
| Clone No. | 1A8 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system. |
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