Recombinant CD4 Monoclonal Antibody (AN300482P)
For research use only.
| Verified Samples |
Verified Samples in IF: Mouse spleen Verified Samples in FCM: BABL/c splenocytes |
| Dilution | ICC/IF 1:100-1:500, FCM 1:100-1:500 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse |
| Applications | FCM, ICC/IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse CD4 Protein |
| Abbre | CD4 |
| Synonyms | L3T, T-cell surface antigen T4/Leu, T-cell surface glycoprotein CD, L3T4, Ly-4, T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, Cd4, L3T4, CD4mut, p55 |
| Swissprot | |
| Cellular Localization | Cell membrane |
| Tissue Specificity | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Clone No. | 5C8 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. |
Other Clones
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Other Formats
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Unconjugated
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