Recombinant CD3D & CD3E Monoclonal Antibody (AN300594P)

Name: Recombinant CD3D & CD3E Monoclonal Antibody
Brand: Elabscience
SKU: AN300594P
Price: 150.0 USD
Availability: InStock

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Recombinant CD3D & CD3E Monoclonal Antibody - 1

All	Size	Price	Qty
	100μL	$ 380.00	- +
	20μL	$ 150.00	- +

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Verified Samples	Verified Samples in IHC: Human tonsil, cynomolgus macaque tonsil, cynomolgus macaque lymphnode, cynomolgus spleen, cynomolgus lymph node Verified Samples in FCM: Human whole blood lymphocytes
Dilution	IHC-P 1:100-1:500, FCM 1:25-1:100
Isotype	IgG
Host	Rabbit
Reactivity	Human
Applications	IHC-P, FCM
Clonality	Monoclonal
Immunogen	Recombinant Human CD3D & CD3E Heterodimer protein
Abbre	CD3D & CD3E
Synonyms	IMD, CD3E, IMD18, T3E, TCRE, CD3e molecule, CD3 epsilon, T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, T3, CD_antigen: CD3e, epsilon,
Swissprot	P07766&P04234
Concentration	1 mg/mL
Buffer	0.2 μm filtered solution in PBS
Purification Method	Protein A
Research Areas	Immunology, Stem Cells
Clone No.	12B12
Conjugation	Unconjugated
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Shipping	Ice bag
background	The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.