Recombinant CD132/IL2RG Monoclonal Antibody (AN300473P)
For research use only.
| Verified Samples |
Verified Samples in IF: Mouse splenocytes Verified Samples in FCM: BABL/c splenocytes |
| Dilution | ICC/IF 1:20-1:100, FCM 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse |
| Applications | FCM, ICC/IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse CD132/IL2RG Protein |
| Abbre | IL2RG |
| Synonyms | CD132, Cytokine receptor common subunit gamma, gammaC, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, Interleukin-2 receptor subunit gamma, p64, Il2rg, common &, gamma- chain-n, IL-2R&, gamma, gamma(c) |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Clone No. | 4D5 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency. |
Other Clones
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Other Formats
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Unconjugated
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