Recombinant Cavia porcellus CTLA-4/CD152 Protein (His Tag) (PKSQ050093)
For research use only.
| Synonyms | CD152, CTLA-4, CTLA4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4 |
| Species | Cavia porcellus |
| Expression Host | P.Pichia |
| Sequence | Ala37-Asp161 |
| Accession | H0VUB1 |
| Calculated Molecular Weight | 16-35 kDa |
| Observed Molecular Weight | 18-40 kDa |
| Tag | C-His |
| Bio-activity | Immobilized Mouse B7-1-Fc at 5 μg/ml (100 μl/well) can bind Cavia porcellus CTLA-4-His. The ED50 of Recombinant Cavia porcellus CTLA-4-His is 4.29 ng/ml. |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
| Background | Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4. |
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