Recombinant Bcl-2 Monoclonal Antibody (AN300032P)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human tonsil, Human sarcoma Verified Samples in FCM: Jurkat |
| Dilution | IHC-P 1:250-1:1000, FCM 1:25-1:100, |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P, FCM |
| Clonality | Rabbit Monoclonal |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Human Bcl-2. |
| Abbre | BCL2 |
| Synonyms | B-cell Lymphoma, PPP1R, BCL, Bcl-2, PPP1R50, BCL2, apoptosis regulator Bcl-2, B-cell Lymphoma 2, apoptosis regulator Bcl-2, Bcl-2, PPP1R50, Apoptosis regulator Bcl 2, Apoptosis regulator Bcl2, AW986256, B cell CLL/lymphoma 2, B cell leukemia/lymphoma 2, B-cell, C430015F12Rik, D630044D05Rik, D830018M01Rik, Leukemia/lymphoma, Oncogene B-cell leukemia 2, Protein phosphatase 1, regulatory subunit 50, Bcl2 |
| Swissprot | |
| Cellular Localization | Mitochondrion outer membrane, Nucleus membrane, Cytoplasm |
| Tissue Specificity | Expressed in a variety of tissues. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Cell Biology, Signal Transduction, Cancer, Kits, Lysates, Other, Metabolism |
| Clone No. | 8D4 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability. Bcl-2 is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. Natural Bcl-2 contains a carboxyl-terminal mitochondria targeting sequence. Recombinant Bcl-2, missing the mitochondrial targeting sequence, maintains its ability to neutralize pro-apoptotic Bcl-2 family members. Neutralization by Bcl-2 appears to be through binding the BH3 region of pro-apoptotic Bcl-2 family members. This activity does not require the mitochondrial targeting sequence. |
Other Clones
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Unconjugated
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