Recombinant ASGPR1/ASGR1 Monoclonal Antibody (AN300469P)
For research use only.
| Verified Samples | Verified Samples in IHC: Mouse liver |
| Dilution | IHC-P 1:250-1:1000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse |
| Applications | IHC-P |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse ASGPR1/ASGR1 protein |
| Abbre | ASGR1 |
| Synonyms | Asgr-1, Asgr1, ASGPR1, Asgr, HL-1 |
| Swissprot | |
| Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Clone No. | 9B10 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development. |
Other Clones
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Unconjugated
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