RBP4 Monoclonal Antibody (AN200017P)
For research use only.
| Verified Samples | Verified Samples in IHC: Human pancreas, Human liver, Human kidney |
| Dilution | IHC-P 1:50-1:200, |
| Isotype | IgG1 |
| Host | Mouse |
| Reactivity | Human |
| Applications | IHC-P |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human RBP4 protein |
| Abbre | RBP4 |
| Synonyms | RET, PRO, Retinol-binding protein, MCOPCB, RBP4, MCOPCB10, RDCCAS, RBP-4, RET4, PRBP, RBP, Retinol-binding protein 4, Plasma retinol-binding protein, Cleaved into Plasma retinol-binding protein, Plasma retinol-binding protein 1-181, Plasma retinol-binding protein 1-179, Plasma retinol-binding protein(1-176), PRO2222 |
| Swissprot | |
| Cellular Localization | Secreted |
| Tissue Specificity | Detected in blood plasma and in urine (at protein level). |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Signal Transduction, Epigenetics and Nuclear Signaling, Cardiovascular, Metabolism |
| Clone No. | 7F15 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Retinol (also known as vitamin A) is unstable and insoluble in the aqueous solution. However, retinol becomes quite stable and soluble in plasma due to its tight interaction with retinol-binding protein 4 (RBP4), also known as plasma retinol-binding protein. A prototypic member of the lipocalin superfamily, RBP4 has a beta -barrel structure with a well-defined cavity. It is secreted from the liver, a process requiring the availability of retinol. RBP4 delivers retinol from the liver to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), also known as thyroxine-binding protein and prealbumin. The retinol-RBP4-TTR complex prevents the loss of RBP4 by filtration through the kidney and increases the stability of the retinol-RBP4 complex. Defects in RBP4 cause retinol-binding protein deficiency, which affects night vision. |
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Unconjugated
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