RBL2 Polyclonal Antibody (E-AB-19324)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human ovarian cancer |
| Dilution | IHC 1:30-1:150 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human RBL2 |
| Abbre | RBL2 |
| Synonyms | 130 kDa retinoblastoma associated protein, 130 kDa retinoblastoma-associated protein, IB4, PPAR-alpha-interacting complex protein 128, PRB2, RBL2, RBR 2, RBR-2, RBR2, Rb2, Rbl2, Retinoblastoma like 2, Retinoblastoma-like protein 2, Retinoblastoma-related protein , p130 |
| Swissprot | |
| Cellular Localization | Nucleus. |
| Concentration | 0.8 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
Other Clones
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Other Formats
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Unconjugated
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