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For research use only.
| Background | Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
| Synonyms | Il10, Interleukin-10, CSIF, Cytokine synthesis inhibitory factor, Il-10 |
| Swissprot | |
| Reactivity | Rat |
| Specificity | Detects Rat IL-10 in ELISAs |
| Applications | ELISA |
| Storage | -20℃ |
| Expiration date | 12 months |
| Introduction | This Antibody Pair Kit applies to the sandwich ELISA assay. |
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Biotin
