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Purified Anti-Mouse CD3e Antibody[500A2] (AN003420P)

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AllSizePriceQty
100μg $ 50.00
25μg $ 20.00
100mg $ 3800.00
50mg $ 2700.00
25mg $ 1800.00
5mg $ 540.00
1mg $ 148.00
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For research use only.

Alternate NamesT3E,  T-cell surface antigen T3/Leu-4 epsilon chain,  T-cell surface glycoprotein CD3 epsilon chain,  Cd3e,  T3,   CD3epsilon
Clone No
Leadtime Inquire
Verified SamplesVerified Samples in FCM: C57/BL6 Mouse splenocytes
DilutionFCM 2 μg/mL(1×105-5×105 cells)
BackgroundPart of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region
ImmunogenRecombinant Mouse CD3e protein
AbbreCD3e
Swissprot
HostSyrian Hamster
ReactivityMouse
ClonalityMonoclonal
Purification Method>98%, Protein A/G purified
Isotype Syrian Hamster IgG
Applications
FCM
Concentration
≥ 1 mg/mL
ConjugationUnconjugated
Storage BufferPhosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
StorageStore at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Expiration Date12 months
ShippingIce bag
Other Clones

1 Results

    Other Formats

    1 Results

    Elab Bright Violet 421

    Elab Bright Violet 510

    Elab Bright Violet 650

    None (AF/LE)

    Unconjugated

      Product Information