Purified Anti-Mouse CD172a Antibody[P84] (E-AB-F1286A)
For research use only.
| Alternate Names | Myd, SHPS, Ptpns, Bit, Myd1, Ptpns1, Shps1, Sirp, Sirpa, SIRP&, beta-1-1, SIRP&, alpha, SIRP&, beta, AI835480, CD172a, P84, SHP-1, SHPS-1 |
| Clone No | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: C57/BL6 Mouse bone marrow |
| Dilution | FCM 2 μg/mL(1×105-5×105 cells) |
| Background | Immunoglobulin-like cell surface receptor for CD47. Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA. In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production. |
| Immunogen | Recombinant Mouse CD172a protein |
| Abbre | CD172a |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Rat IgG1, κ |
| Applications |
FCM
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
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Other Formats
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Elab Fluor®488
Elab Fluor®700
FITC
None (AF/LE)
Unconjugated
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