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| Alternate Names | TKR, ERBB, erb-b2 receptor tyrosine kinase, Receptor tyrosine-protein kinase erbB, Tyrosine kinase-type cell surface receptor HER, HER2/ErbB, HER, MLN, ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2, HER2/ErbB2, MLN19, Metastatic lymph node gene 19 protein, p185, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2, Neu, erb-B2, CD340, erb-b2 receptor tyrosine kinase 2, HER2, HER-2, HER-2/neu, MLN 19, MLN19, NGL, TKR1, C erb B2/neu protein, CD340 antigen, Cerb B2/neu protein, CerbB2, ENV, ENVW, Erb b2 receptor tyrosine kinase 2, ERVWE1, HER 2, HER 2/NEU, Herstatin, HERV7Q, HERV-7q, HERVW, HERVWENV, HERV-W-ENV, Human epidermal growth factor receptor 2, NEU proto oncogene, neuro/glioblastoma derived oncogene homolog, neuro/glioblastoma derived oncogene homolog (avian), Neuroblastoma/glioblastoma derived oncogene homolog, p185erbB2, Proto-oncogene c-ErbB-2, Tyrosine kinase type cell surface receptor HER2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog), V erb b2 avian erythroblastic leukemia viral oncoprotein 2, V erb b2 erythroblastic leukemia viral oncogene homolog 2, Verb b2 erythroblastic leukemia viral oncogene homolog 2 |
| Clone No | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: MCF-7 |
| Dilution | FCM 2 μg/mL(1×105-5×105 cells) |
| Background | ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system. |
| Immunogen | Recombinant Human CD340 protein |
| Abbre | CD340 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG2b, κ |
| Applications | FCM |
| Research Areas | Tags & Cell Markers;Signal Transduction;Cancer |
| Concentration | ≥ 1 mg/mL |
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
1 Results
Other Formats
1 Results
Unconjugated
