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| Alternate Names | MDR, PGY, ABC, ABCB, P-glycoprotein, Phospholipid transporter ABCB, ATP-dependent translocase ABCB, ATP-binding cassette sub-family B member, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, P Glycoprotein, ABCB1, ATP-binding cassette sub-family B member 1, ATP-dependent translocase ABCB1, P-glycoprotein 1, Phospholipid transporter ABCB1, MDR-1, P-gp, gp170, ABC-B1, ATP binding cassette, Colchicin sensitivity, Doxorubicin resistance, member 1, Multidrug resistance 1, Multidrug resistance protein 1, P glycoprotein 1, P gp, sub family B (MDR/TAP) |
| Clone No | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution | FCM 2 μg/mL(1×105-5×105 cells) |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. |
| Immunogen | Recombinant Human CD243 protein |
| Abbre | CD243 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse BALB/c IgG1, V-KAPPA |
| Applications | FCM |
| Research Areas | Signal Transduction;Stem Cells;Cancer |
| Concentration | ≥ 1 mg/mL |
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
1 Results
Other Formats
1 Results
Unconjugated
