Purified Anti-Human CD192 Antibody[K036C2] (E-AB-F1385A)
For research use only.
| Alternate Names | CKR, CMKBR, CC-CKR, CCR, CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, FLJ78302, C C chemokine receptor type 2, C C CKR 2, CC chemokine receptor type 2, C-C chemokine receptor type 2, CC CKR 2, C-C CKR-2, CCCKR2, CCR 2, CCR1L, CCR5L, CD192 antigen, Chemokine C C motif receptor 2, Chemokine CC Motif Receptor 2, CKR 2, cluster of differentiation 192, MCP 1 R, MCP1 RECEPTOR, MCP1R, MCP-1-R, Monocyte chemoattractant protein 1 receptor, Monocyte Chemotactic Protein 1 Receptor |
| Clone No | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: Human peripheral blood monocytes cell |
| Dilution | FCM 2 μg/mL(1×105-5×105 cells) |
| Background | CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation. |
| Immunogen | Recombinant Human CD192 protein |
| Abbre | CD192 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG2a, κ |
| Applications |
FCM
|
| Research Areas | Immunology;Microbiology;Signal Transduction;Cancer;Cardiovascular |
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
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Other Formats
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APC
Elab Fluor®488
PE
PerCP/Cyanine 5.5
Unconjugated
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