Purified Anti-Human CD135 Antibody[4G8] (AN004060P)
For research use only.
| Alternate Names | Fetal Liver Kinase, Fms-Like Tyrosine Kinase, Stem Cell Tyrosine Kinase, Receptor-Type Tyrosine-Protein Kinase FLT, FLT, FLK, STK, FLT3, CD135, FLK-2, FLK2, STK1, Fetal Liver Kinase-2, FL Cytokine Receptor, FLT-3, Fms-Like Tyrosine Kinase 3, Receptor-Type Tyrosine-Protein Kinase FLT3, Stem Cell Tyrosine Kinase 1, STK-1, Flt3/Flk2, STK-1, CD 135, CD135 antigen, Fetal liver kinase 2, Flk 2, Flt 3, FMS like tyrosine kinase 3, Fms related tyrosine kinase 3, Fms-Related Tyrosine Kinase 3, Growth factor receptor tyrosine kinase type III, Ly-72, OTTHUMP0000004234, Receptor type tyrosine protein kinase FLT3, Stk 1, Tyrosine protein kinase receptor FLT3, Tyrosine-protein kinase receptor FLT3 |
| Clone No | |
| Leadtime | Inquire |
| Dilution | FCM 2 μg/mL(1×105-5×105 cells) |
| Background | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
| Immunogen | Recombinant Human CD135 protein |
| Abbre | CD135 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse BALB/c IgG1, κ |
| Applications |
FCM
|
| Research Areas | Immunology;Signal Transduction |
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
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Unconjugated
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