Purified Anti-Human ADAM10 Antibody[11G2] (AN003550P)
For research use only.
| Alternate Names | CDw, ADAM, ADAM metallopeptidase domain, a disintegrin and metalloprotease domain, a disintegrin and metalloproteinase domain, disintegrin and metalloproteinase domain-containing protein, ADAM10, AD10, AD18, CD156c, CDw156, HsT18717, MADM, RAK, kuz, Kuzbanian, a disintegrin and metalloprotease domain 10, a disintegrin and metalloproteinase domain 10, ADAM metallopeptidase domain 10, CD156c antigen, disintegrin and metalloproteinase domain-containing protein 10, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, ADAM metallopeptidase domain 10, CD156c, CDw156, HsT18717, kuz, MADM, AD 10, ADA10, ADAM 10, CD 156c, disintegrin and metalloproteinase domain containing protein 10, Drosophila, homolog of, HsT 18717, Mammalian disintegrin metalloprotease |
| Clone No | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution | FCM 2 μg/mL(1×105-5×105 cells) |
| Background | ADAM10 (also known as Kuzbanian, mammalian disintegrin metalloprotease, myelin-associated metalloproteinase) is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain . Like other membrane-anchored ADAMs, ADAM10 consists of the following domains, pro with a cysteine switch and furin cleavage sequence, catalytic with the zinc-binding site and Met-turn expected for reprolysins, disintegrin-like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic. ADAM10 is highly conserved, with 97% amino acid identity between mouse, rat, bovine and human and 45% identity between mouse and Drosophila. The active enzyme processes notch, notch ligand delta, and amyloid protein precursor at the alpha site, playing an important role in neurogenesis . It also processes the 26 kDa membrane-anchored pro-tumor necrosis factor-alpha (TNF-alpha ) to the 17 kDa mature TNF-alpha. It cleaves myelin basic protein and type IV collagen. ADAM10 is widely expressed in tissues and resides both on the cell surface and in the cell. |
| Immunogen | Recombinant Human ADAM10 protein |
| Abbre | ADAM10 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Applications |
FCM
|
| Research Areas | Cell Biology;Signal Transduction;Cancer |
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
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Unconjugated
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