PKC gamma Polyclonal Antibody (E-AB-16194)
For research use only.
| Verified Samples |
Verified Samples in WB: Mouse brain |
| Dilution | WB 1:500-1:2000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human PRKCG |
| Abbre | PRKCG |
| Synonyms | KPCG, MGC57564, OTTHUMP00000067291, PKC-gamma, PKCC, PKCG, PRKCG, Protein kinase C, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, SCA 14, SCA14, gamma |
| Swissprot | |
| Calculated MW | 78 kDa |
| Cellular Localization | Cytosol, Nucleus, Plasma Membrane, synaptic membrane, Other locations: cell-cell junction, dendrite, intracellular, perinuclear region of cytoplasm, postsynaptic density. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). |
Other Clones
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Unconjugated
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