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Phospho-ERK 1/2 (Tyr222/205) Monoclonal Antibody (E-AB-51039)

AllSizePriceQty
200μL $ 399.00
120μL $ 240.00
60μL $ 143.00
20μL $ 73.00
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For research use only.

Verified Samples Verified Samples in IHC: Human colon carcinoma, Human breast carcinoma
Dilution IHC 1:100-200
Isotype IgG
Host Mouse
Reactivity Human,  Mouse,  Rat
Applications IHC-p
ClonalityMonoclonal
ImmunogenSynthetic Peptide of Phospho-ERK 1/2 (Tyr222/205)
AbbrePhospho-ERK 1/2 (Tyr222/205)
SynonymsERK-1,  ERK1,  ERT2,  Extracellular signal-regulated kinase 1,  Insulin-stimulated MAP2 kinase,  MAP kinase 3,  MAP kinase isoform p44,  MAPK 3,  MAPK3,  Microtubule-associated protein 2 kinase,  Mitogen-activated protein kinase 3,  PRKM3,  p,  p44-MAPK
Swissprot
Cellular LocalizationNucleus.
Concentration1 mg/mL
BufferPhosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
Purification MethodProtein A purification
Research AreasCancer,  Signal Transduction,  Neuroscience
Clone No.4D4
ConjugationUnconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
ShippingThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
backgroundInvolved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Other Clones

1 Results

    Other Formats

    1 Results

    Unconjugated

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