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For research use only.

Verified Samples Verified Samples in IHC: Human prostate cancer, Human brain
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human EIF2AK3
Abbre EIF2AK3
Synonyms DKFZp781H1925,  E2AK3,  EC 2.7.11.1,  Eif2ak3,  Eukaryotic translation initiation factor 2 alpha kinase 3,  Eukaryotic translation initiation factor 2-alpha kinase 3,  HRI,  Heme regulated EIF2 alpha kinase,  HsPEK,  Pancreatic eIF2 alpha kinase,  Pancreatic eIF2-alpha kinas
Swissprot
Cellular Localization Endoplasmic reticulum membrane.
Concentration 0.5 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Epigenetics and Nuclear Signaling,  Metabolism
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis.It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins.Mutations in this gene are associated with Wolcott-Rallison syndrome.
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Unconjugated

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