NARF Polyclonal Antibody (E-AB-18713)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human ovarian cancer |
| Dilution | IHC 1:50-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human NARF |
| Abbre | NARF |
| Synonyms | DKFZp434G0420, FLJ10067, GC17P078009, IOP2, Iron only hydrogenase like protein 2, Nuclear prelamin A recognition factor, Prenyl dependent prelamin A binding protein |
| Swissprot | |
| Cellular Localization | Nuclear |
| Concentration | 1.56 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling, Neuroscience, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends.Prenylation was initially believed to be important only for membrane attachment.However, another role for prenylation appears to be its importance in protein-protein interactions.The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins.Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif.This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A.The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain.It may be a component of a prelamin A endoprotease complex.The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina.It shares limited sequence similarity with iron-only bacterial hydrogenases.Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. |
Other Clones
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Other Formats
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Unconjugated
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