Mouse OxLDL Antibody Pair Set (E-KAB-0682)
For research use only.
| Background |
Receptor that mediates the recognition,internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction,resulting in pro-inflammatory responses,pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release,monocyte adhesion and apoptosis. In addition to binding oxLDL,it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells,thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process,by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products,activated platelets,monocytes,apoptotic cells and both Gram-negative and Gram-positive bacteria.
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| Synonyms |
CLEC8A, CLEC8ASLOX1, C-type lectin domain family 8 member A, hLOX-1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, LOX1, LOX-1, LOX1ox LDL receptor 1, LOXIN, OLR1
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| Reactivity |
Mouse
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| Specificity |
Detects Mouse OxLDL in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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| Introduction |
This ELISA kit applies to the in vitro quantitative determination of Mouse OxLDL concentrations in serum, plasma and other biological fluids.
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