Mouse IL-4 Antibody Pair Set (E-KAB-0549)

Cytokine secreted primarily by mast cells , T-cells , eosinophils , and basophils that plays a role in regulating antibody production , hematopoiesis and inflammation , and the development of effector T-cell responses.Induces the expression of class II MHC molecules on resting B-cells.Enhances both secretion and cell surface expression of IgE and IgG1.Regulates also the expression of the low affinity Fc receptor for IgE ( CD23 ) on both lymphocytes and monocytes.Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.In addition , plays a critical role in higher functions of the normal brain , such as memory and learning.Upon binding to IL4 , IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex , located mainly on hematopoietic cells , or with the IL13RA1 to produce the type 2 complex , which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.

IL4, BCGF-1, BCGF1, BSF-1, BSF1

Mouse

Detects Mouse IL-4 in ELISAs

ELISA

-20℃

12 months