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For research use only.
| Background | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor ( TCR ) -mediated T-cell activation. Acts as a positive regulator of T-cell coactivation , by binding at least ADA , CAV1 , IGF2R , and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix ( ECM ) , the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion , migration and tube formation. When overexpressed , enhanced cell proliferation , a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation , including many chemokines , mitogenic growth factors , neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. |
| Synonyms | ADABP, ADCP2, Adenosine Deaminase Complexing Protein 2, CD26, DPPIV, TP103 |
| Swissprot | |
| Reactivity | Mouse |
| Specificity | Detects Mouse DPP4 in ELISAs |
| Applications | ELISA |
| Storage | -20℃ |
| Expiration date | 12 months |
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Biotin
