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For research use only.
| Background | Part of the receptor for interleukin 6. Binds to IL6 with low affinity , but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response , acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling' , the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively , 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. |
| Synonyms | C3d |
| Swissprot | |
| Reactivity | Mouse |
| Specificity | Detects Mouse C3d in ELISAs |
| Applications | ELISA |
| Storage | -20℃ |
| Expiration date | 12 months |
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