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For research use only.

Verified Samples Verified Samples in IHC: Human cervical cancer, Human colorectal cancer
Dilution IHC 1:50-1:300
Isotype IgG
Host Rabbit
Reactivity Human,  Rat
Applications IHC
Clonality Polyclonal
Immunogen Fusion protein of human MDFI
Abbre MDFI
Synonyms I MF,  I mfa,  Inhibitor of MyoD family a,  MDFI,  Mdfi,  MyoD family inhibitor,  Myogenic repressor I-mf,  OTTHUMP00000016375,  OTTHUMP00000016376,  OTTHUMP00000196103,  OTTHUMP00000196414,  OTTHUMP00000196415
Swissprot
Cellular Localization Nucleus. Cytoplasm.
Concentration 0.84 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Epigenetics and Nuclear Signaling,  Developmental Biology
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.MDFI (MyoD Family Inhibitor) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is MDFIC.
Other Clones

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Unconjugated

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