MCM10 Polyclonal Antibody (E-AB-52160)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human thyroid cancer, Human ovarian cancer |
| Dilution | IHC 1:35-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human MCM10 |
| Abbre | MCM10 |
| Synonyms | MCM10 Minichromosome Maintenance Deficient 10 , CNA43, DNA43, Homolog Of Yeast MCM10, HsMCM10, Minichromosome Maintenance 10 Replication Initiation Factor, Minichromosome Maintenance Complex Component 10, PRO2249, Protein MCM10 Homolog |
| Swissprot | |
| Cellular Localization | Nucleus |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. |
Other Clones
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Other Formats
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Unconjugated
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