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For research use only.

Verified Samples Verified Samples in IHC: Rat heart, Human appendix, Mouse heart
Verified Samples in IF: MCF-7
Dilution IHC 1:50-1:200,  IF 1:50-1:100
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IHC,  IF
Clonality Polyclonal
Immunogen Recombinant fusion protein of human MAP2K5 (NP_660143.1).
Abbre MAP2K5
Synonyms HsT17454,  MAP2K5,  MAPKK5,  MEK5,  PRKMK5
Swissprot
Cellular Localization Cytoskeleton, spindle, Cytosol, Nucleus, Other locations: cytoplasm.
Concentration 1 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Cardiovascular,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
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Unconjugated

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