KDM2A Polyclonal Antibody (E-AB-19855)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human thyroid cancer |
| Dilution | IHC 1:50-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human KDM2A |
| Abbre | KDM2A |
| Synonyms | CXXC-type zinc finger protein 8, CXXC8, F box / LRR repeat protein 11, F box and leucine rich repeat protein 11, F box protein FBL7, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LR, [Histone-H3]-lysine-36 demethylase 1A |
| Swissprot | |
| Cellular Localization | Nucleus>nucleoplasm. Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2. |
| Concentration | 1.74 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. |
Other Clones
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Other Formats
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Unconjugated
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