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For research use only.
Verified Samples | Verified Samples in IHC: Human colon cancer |
Dilution | IHC 1:50-1:200 |
Isotype | IgG |
Host | Rabbit |
Reactivity | Human |
Applications | IHC |
Clonality | Polyclonal |
Immunogen | Synthetic peptide of human ITPR2 |
Abbre | ITPR2 |
Synonyms | 4, 5-trisphosphate receptor, 5-trisphosphate receptor type 2, IP3 R2, IP3 receptor, IP3 receptor isoform 2, IP3R 2, IP3R2, ITPR 2, ITPR2, Inositol 1, Inositol 1 4 5 trisphosphate receptor type 2, Inositol 145 trisphosphate receptor type 2, InsP3 R2, InsP3R2, Itpr2, Typ |
Swissprot | |
Cellular Localization | Endoplasmic reticulum membrane. |
Concentration | 0.9 mg/mL |
Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
Purification Method | Affinity purification |
Research Areas | Cancer, Metabolism, Signal Transduction |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
background | Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver. |
Other Clones
1 Results
Other Formats
1 Results
Unconjugated
