INS Polyclonal Antibody (E-AB-67409)

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For research use only.
Verified Samples |
Verified Samples in IHC: Rat pancreatic islet, Mouse pancreatic islet Verified Samples in IF: Rat pancreas, Mouse pancreas |
Dilution | IHC 1:50-1:200, IF 1:50-1:200 |
Isotype | IgG |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Applications | IHC, IF |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein of human INS (NP_000198.1). |
Abbre | INS |
Synonyms | IDDM, IDDM1, IDDM2, ILPR, INS, IRDN, Insulin, MODY10, insulin |
Swissprot | |
Cellular Localization | Secreted. |
Concentration | 1 mg/mL |
Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
Purification Method | Affinity purification |
Research Areas | Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
background | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. |
Other Clones
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Other Formats
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Unconjugated
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