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For research use only.
Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. |
Synonyms | CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR, Etanercept, P75tbpii, TNF-R2, CD120b antigen, |
Swissprot | |
Reactivity | Human |
Specificity | Detects Human TNFRSF1B in ELISAs |
Applications | ELISA |
Storage | -20℃ |
Expiration date | 12 months |
Introduction | This Antibody Pair Kit applies to the sandwich ELISA assay. |
Other Clones
1 Results
Other Formats
1 Results
Biotin
